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Cholesterol-lowering drug atorvastatin - ScienceDirect 1 Jan 2025 · Taking the CHL-lowering drug Atorvastatin as an example, it focuses on the target and mechanism of action of statin drugs, their design and synthesis, structure-activity …
Atorvastatin - an overview | ScienceDirect Topics Atorvastatin 15, a blockbuster ‘statin’ drug developed by Pfizer, is used to treat hypercholesterolemia. Atorvastatin is a competitive inhibitor of HMG-CoA reductase and as …
Atorvastatin Calcium - ScienceDirect 1 Jan 2010 · Atorvastatin calcium is also indicated to reduce the total cholesterol and low-density lipoprotein cholesterol (LDL-C) in patients with homozygous familial hypercholesterolemia …
1 The Discovery and Development of Atorvastatin, A Potent Novel ... 1 Jan 2002 · In addition to development of the structure-activity relationships which led to atorvastatin calcium, another critical aspect of the development of this area was the parallel …
Atorvastatin - an overview | ScienceDirect Topics Atorvastatin Atorvastatin is a strong statin currently in worldwide clinical use. Atorvastatin presents a somewhat less lipophilic nature and an inability to cross the BBB to any significant extent. …
Spatial structure of atorvastatin and its complex with model … 5 Sep 2018 · Intermolecular complex of atorvastatin with dodecylphosphocholine (DPC) micelle was investigated by NMR and computational methods. The results of NMR experiments …
The persistence and crystallization behavior of atorvastatin … 1 Jun 2022 · The crystalline form of atorvastatin calcium (ATC) is hydrated and at room temperature under a relative humidity of about 50%, it contains three water molecules [8]. On …
Spatial structure of atorvastatin and its complex with model … 5 Sep 2018 · Structure of molecular complex atorvastatin + DPC micelle differs from previously studied by us complexes of the model membranes with pravastatin, cerivastatin and …
Statins in therapy: Understanding their hydrophilicity, lipophilicity ... 6 Oct 2014 · Statins in therapy: Understanding their hydrophilicity, lipophilicity, binding to 3-hydroxy-3-methylglutaryl-CoA reductase, ability to cross the blood brain barrier and metabolic …
Medicinal chemistry and pharmacology of statins - ScienceDirect 1 Jan 2022 · Polar interactions between HMG-CoA reductase and the 3,5-dihydroxyheptanoic acid are conserved between cocrystal structures. However, atorvastatin and rosuvastatin …